ABSTRACT
The treatment of articular cartilage (AC) injury caused by various reasons is still a major clinical problem. The emergence of cartilage tissue engineering brings new hope for the treatment of AC injury. In general, AC tissue engineering can be divided into two categories, including cell-based tissue engineering and cell-free tissue engineering. Although cell-based tissue engineering can repair cartilage damage to a certain extent, existing therapeutic strategies still suffer from limited cell sources, high costs, risk of disease transmission, and complex procedures. However, the cell-free tissue engineering avoids these shortcomings and brings hope for in-situ AC regeneration. Non-cellular tissue engineering is mainly used to recruit endogenous stem cells/progenitor cells (SCPCs) to reach the site of cartilage injury, and provide a suitable regenerative microenvironment to promote cell proliferation and chondrogenic differentiation, then the maturation of new cartilage tissue was promoted. Therefore, it is also called as cell-homing in situ tissue engineering. Successful recruitment of endogenous SCPCs is the first step in in-situ cartilage tissue engineering. This review aims to introduce chemokine response of cartilage injury, systematically summarize traditional chemoattractant (chemokines and growth factors etc.) and emerging chemoattractant (functional peptides, exosomes and nucleic acid adapters etc.), evaluate the combination mode between chemoattractant and delivery devices, discuss the prospects and challenges of chemoattractant-mediated in situ tissue engineering and provide theoretical basis for the design of endogenous SCPCs homing-based in situ tissue engineering.
ABSTRACT
@#Objective To explore nursing for defecation of the patients with hip or knee replacement before and after arthroplasty.Methods 30 patients with selective bilateral hip or knee replacement were observed at different phases, including interval time, duration, score of oneself subject feeling, and rate of negative symptoms.Results ① Interval time and duration of defecation was longer after arthroplasty than before arthroplasty (P<0.05)；The index mentioned above of the second defecation was shorter than the first one(P<0.05). ②The score of oneself subject feeling and rate of negative symptoms were higher after arthroplasty than before arthroplasty(P<0.05); The index mentioned above of the second defecation was lower than the first one(P<0.05).Conclusion Difficult defecation happens to the patients with arthroplasty and the nurse should screen susceptible patients before operation, then highlight the key links and give nursing intervention in order to assist defecation.